| F of I | Figure of Insensitiveness (explosives) |
| F | Farad |
| F | Phenylalanine (amino acid) |
| F4TCNQ | 2,3,5,6-Tetrafluoro-7,7,8,8-tetracyanoquinodimethane |
| FA | Fluorescent Antibody |
| FAAS | Flameless Atomic Absorption Spectrometry |
| FAB | Fast atom bombardment |
| FACA | Federal Advisory Committees Act (US) |
| FACSS | Federation of Analytical Chemistry and Spectroscopy Societies |
| FAME | Fatty Acid Methyl Ester |
| FAMS | Foundation for Advances in Medicine and Science |
| FAMSO | Methyl methylsulfinylmethyl sulfide |
| FAQ | Frequently Asked Questions |
| FAS | Federation of American Scientists |
| FASB | Financial Accounting Standards Board |
| FAW | Forschungsinstituty für andwendungsorientierte Wissensverarbeitung |
| FBS | Fetal Bovine Serum |
| FC | Forward Curve (centrifugal blower) |
| FCC | Food Chemical Codex |
| FCC | Federal Communications Commission |
| FCCSET | Federal Coordinating Council on Science, Engineering & Technology |
| FCS | Fetal calf serum |
| FDA | (U. S.) Food and Drug Administration |
| FD&C | Food, Drug & Cosmetic (often used in colorant designations) |
| FDC | FDA Modernization Act (US) |
| FDC | (U. S. Federal) Food, Drug and Cosmetic (Act) |
| FDC | Fire Direction Center(military) |
| FDDI | Fiber Distributed Data Interface |
| FDM | Frequency division multiplex |
| FDR | Former US President Franklin Delano Roosevelt |
| FEL | Free-Electron Laser |
| FeLV | Feline leukemia virus |
| FEMA | Federal Emergency Management Agency |
| FEP | Free Erythrocyte Protoporphyrin |
| FET | Field Effect Transistor |
| FEUM | Farmacopea de los Estados Unidos Mexicanos |
| FEV1 | Forced Expiratory Volume (1 second) |
| FFAP | Free Fatty Acid Phase |
| FFF | Field Flow Fractionation |
| FFL | Federal Firearms License (US, required for dealers) |
| FFT | Fast Fourier Transform |
| FG42 | Fallschirmjägergewehr model 1942 (paratroop light MG) |
| FGAN | Fertilizer grade ammonium nitrate |
| FIA | Flow Injection Analysis |
| FID | Flame Ionization Detector (Gas chromatography) |
| FIFO | First in, first out (inventory accounting) |
| FIFRA | Federal Insecticide, Fungicide and Rodenticide Act |
| FIM | Facing Identification Mark(U. S. Postal Service) |
| FIPA | Flow injection polymer analysis |
| FIS | Führungs (or Fach-) Informations System |
| FISH | Fluorescence in situ hybridization |
| FITC | Fluorescein isothiocyanate |
| FLA | Full-Load Amps |
| FLIR | Forward-Looking Infrared |
| FLL | Forschungsgesellschaft Landschaftsentwicklung und Landschaftsbau |
| FLOX | Liqid fluorine dissolved in liquid oxygen |
| FM | Frequency Modulation |
| FM | (U. S. Army) Field Manual |
| FMC | Food Machines and Chemical Company |
| FMECA | Failure mode, effect and criticality analysis |
| FMOC | 9-fluorenylmethoxycarbonyl- |
| FMT | Fast-melting tablets (dissolve rapidly in saliva) |
| FN | Fabrique National des Armes de Guerre (Liege) |
| FNMA | Federal National Mortgage Association ("Fannie Mae") |
| FNPS | 4-fluoro-3-nitrophenyl sulfone |
| FOA | Fluoroorotic acid |
| FOKO | Forschungskosten (?) |
| FPD | Flame Photometric Detector (Gas chromatography) |
| FPLC | Fast protein,peptide and polynucleodide liquid chromatography |
| FPM | Feet per minute |
| FQPA | Food Quality Protection Act (US) |
| FR | Federal Register |
| FROG | Frequency-Resolved Optical Gating |
| FRS | Financial Reporting Standard (UK) |
| FS | Federal Standard |
| FS | Fused Silica |
| FS | Full-scale |
| FSCC | Fire Support Coordination Center (military) |
| FSH | Follicle Stimulating Hormone |
| FSIS | Food Safety and Inspection Service (USDA) |
| FSK | Frequency shift keying (radioteletype) |
| FSOT | Fused Silica Open Tubular (GC column) |
| FSR | Free Spectral Range |
| FT | French WWI chem. agent: benzyl iodide + titanium tetrachloride |
| FT | Fourier transform |
| FTA | Fluorescent Treponemal Antibody (Adsorption) |
| FTI | Free Thyroxine Index |
| FTIR | Fourier Transform InfraRed (spectrometry) |
| FTP | File Transfer Protocol |
| FTZ | Fernmeldetechnische Zentralamt |
| FVC | Forced Vital Capacity |
| FWHM | Full Width Half-Maximum |
| FWM | Four-Wave Mixing |
| FWT | Fernwirktechnik (remote control) |
| FY | Fiscal Year |
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