Abbauprodukt
|
Degradation product
|
Abflussrohr
|
Drain pipe
|
Abklatschplatte
|
RODAC plate; contact plate; replica plate (microbiology)
|
Ablaufdatum
|
Expiration date (end of stability period)
|
Ablauffrist
|
Stability period; maximum storage time
|
Abluft
|
Exhaust air (as from a fermentor)
|
Abriebfest
|
Abrasion-resistant(tablet)
|
Abwasser
|
Wastewater(drain, sewer)
|
Analysenwaage
|
Analytical balance (limit ca. 100 g)
See note below
|
Aromastoff
|
Flavoring
|
Arzneiform
|
Dosage form(e. g., a tablet or capsule)
|
Arzneimittel
|
Drug preparation
|
Arzneimittelwirkung
|
(Adverse) drug reaction (as well as the literal
drug effect) |
Arzneistoff
|
Drug substance
|
Aspekt
|
Appearance
|
ätherisches Öl |
Essential oil
|
Auflösungszeit |
Dissolution time
|
Ausschlusskriterien
|
Exclusion criteria (in a clinical trial)
|
Autoklavierband
|
Autoclave tape; used on materials to be autoclaved;
black letters Sterile appear after autoclaving |
Beipackzettel
|
Patient package insert (PPI)
|
BFM; Biofeuchtmass
|
Wet biomass
|
Bindemittel
|
Binder, binding agent (for tablets)
|
biologische Verfügbarkeit |
Bioavailability
|
Bodenventil
|
Bottom valve; base valve
|
Bodenzahl
|
Number of (theoretical) plates (for a chromatograph
column)
|
Bördelkappe |
Crimp cap (on a vial, usually aluminum)
|
Bördelöffner |
Decapper
|
Bördelzange |
Crimper; cap crimper
|
Bruchkerbe
|
Score (notch) on a tablet for breaking
|
Charge
|
Lot, batch
|
CIP
|
Clean(ing) in place
|
Dampfbehandlung
|
Steam treatment; steaming
|
Dosier Aerosol
|
Metered-dose inhaler
|
Dosierung
|
Dosage (to a patient); strength (of a tablet or
capsule)
|
Dragee
|
Sugar-coated tablet
|
Dragierkessel
|
Coating pan
|
Druckentlastung
|
Pressure release; depressurization
|
Druckfestigkeit
|
Hardness (of a tablet)
|
einfüllen |
To fill, or to transfer; perhaps to add
|
Einschlusskriterien
|
Inclusion criteria (in a clinical trial)
|
Einwaage
|
Initial weight; amount added to a reactor
|
Einweg-
|
Disposable
|
Einwiegemenge
|
Amount to be weighed in (to a reactor, fermentor,
etc.
|
Einwilligungserklärung |
Informed consent (signed statement)
|
EP Europäisches Arzneibuch |
European Pharmacopeia
|
Erntebrei
|
Harvest broth (from a fermentor)
|
Etiketten
|
Labels.
|
Etikettenbilanz / -bilanzierung
|
Label accounting. All finished product labels printed
must be accounted for as applied to the product, attached to the
record, or destroyed.
|
EU
|
Entotoxin Unit(s)
|
Extinktion
|
Absorbance (spectrophotometry)
|
Facettenrand
|
Beveled edge of a tablet
|
Falcon
|
Brand name of plastic products
|
Fertig-
|
Ready for use
|
Filterintegritätstest |
Filter integrity test (typically measures resistance
to flow of air under pressure)
|
Filterkerze, Filterpatrone
|
Filter cartridge or filter candle
|
Freigabe, freigeben
|
Release for further processing or for marketing;
Release of active ingredient from a tablet or capsule
|
Freigabeschein
|
Release certificate
|
Galenische
|
Refers to the ancient physician, Galen. Usually
pharmaceutical or pharmacological; Formulation
|
Gehalt
|
Content; may be used to mean Purity
|
Gehaltseinheitlichkeit
|
Content uniformity
|
GMP
|
Good Manufacturing Practice
|
Granulat
|
Granulation (mixture of ingredients prepared for
tabletting)
|
GW gereinigt Wasser |
Purified water
|
Haltbarkeit
|
Stability; storability
|
Herstellungsvorschrift
|
Master formula (production procedure)
|
HETP
|
Height of an equivalent theoretical plate (column
chromatography)
|
Hilfsstoff
|
Excipient
|
Induktion
|
Induction (addition of a substance that induces
production of a desired product)(microbiology) |
in-line
|
In-line. Refers to analytical measurements of material
(especially liquids) in the production line rather than taking samples
to the laboratory for analysis
|
IPA
|
Isopropyl alcohol
|
Ist
|
Is; but often means Actual in
comparison with a Soll or target value |
Istwert
|
Actual value (compared with target value or set
point)
|
Kampagne
|
Campaign; production of a series of lots
|
KBE (koloniebildende Einheit)
|
CFU (colony-forming unit) (microbiology)
|
Kern
|
Core (of a coated tablet)
|
Konservierungsmittel
|
Preservative
|
Kontrolle
|
Check; inspection; examination; occasionally
control |
Kontrollunterschrift
|
Check (or verification) signature
|
künstliche Darmsaft |
Simulated intestinal fluid
|
künstliche Magensaft |
Simulated gastric fluid
|
Lagertank
|
Holding tank
|
Lagerungszeit
|
(Maximum allowed) storage time
|
LAL
|
Limulus amebocyte lysate (test for pyrogens (bacterial
endotoxins))
|
Laminarflow
|
May refer to a laminar flow workbench or the like;
perhaps even a laminar flow clean room
|
Lauge
|
Lye (sodium hydroxide) (solid or solution); alkaline
solution; Liquor
|
Leitfähigkeit |
Conductivity (electrical) of a solution
|
LF
|
Laminar flow; but sometimes Leitfähigkeit
|
LIMS
|
Laboratory information management system
|
Luftzufuhr
|
Air input
|
Magenfest
|
Resistant to stomach conditions; typically
enteric-coated |
Membranpump
|
Diaphragm pump
|
Metrohm
|
A Swiss instrument manufacturer |
Mettler
|
A US
instrument manufacturer
|
Mitarbeiter
|
Operator (of production equipment); technician;
employee
|
Musternahme
|
Sampling; sample collection; taking a sample
|
Nachbereitung
|
Post-processing
|
Nutzwasser
|
Process water; service water
|
Oberflächenbelüftung |
Surface aeration
|
Oberschalenwaage
|
Top-loading balance (see note below)
|
optische Dichte (OD)
|
Literally Optical density. That
is still the term for photographic film, but for spectrophotometric
measurements the accepted term in the US
is Absorbance (A). A subscript will indicate the wavelength for the
measurement. |
PEG
|
Polyethylene glycol
|
PEGylation
|
PEGylation: addition of a PEG chain to a product,
usually a genetically engineered product
|
pH-Korrektur
|
pH adjustment
|
pH-Sonde
|
A pH probe that is inserted into
a reactor or fermenter (not just the electrode pair that might be
used in a beaker) |
pH-Wert
|
pH value, literally, but usually just pH
in US usage |
PPG
|
Polypropylene glycol
|
Protokoll
|
Procedure; Record; often both, as in a Herstellungsprotokoll
which specifies individual steps of the procedure, that are signed
off, when done, as a record that they have been done.
|
Protokollblatt
|
Record sheet
|
Prüfbogen |
Case report form (clinical trial)
|
Qualität |
Quality; for a chemical, Grade, or Purity. Note
that designations of grades such as Chemically Pure are not very
meaningful without data on limits of impurities.
|
Reinigen; Reinigung
|
Clean(ing); Purify, purification. Careful!
A piece of equipment is cleaned, while a product
is purified.
|
Reinst
|
Highest purity (not very meaningful without statement
of limits of impurities)
|
Reinstdampf
|
Clean steam; high-purity steam
|
rezeptflichtige
|
Prescription required
|
Rotrandfilter
|
Red ribbon filter (apparently a type designation
by Schleicher & Schüll) |
Rückhaltemuster |
Retained sample
|
Rückhalteprobe |
Retained sample
|
Schlauchquetschpumpe
|
Peristaltic pump
|
Schleuse
|
Lock (air lock) for transferring material into
and out of a clean room or the like
|
schliff-
|
May indicate ground glass; e.
g., Erlenmeyerschliffkolben: an Erlenmeyer flask with a ground-glass
stopper |
Schüttelkolb |
Shake flask (for microbial culture)
|
Schwerwiegendes unwerwünschtes Ereignis
|
Severe adverse event (clinical trial)
|
SET Systemeignungstest
|
System suitability test; a test to make sure that
an analytical system (especially a chromatograph) is capable of
performing a particular analysis.
|
Silikonschlauch / Siliconschlauch
|
Silicone hose (not silicon)
|
SIP
|
Sterilize/Sterilization in place
|
Sollwert, Sollgewicht
|
Target value; desired value; set-point for a controller; in some cases, theoretical value
|
sperren
|
Block; often Quarantine, in the sense of not using
or selling a material until it has passed all the required tests
|
Stamm
|
Strain (of microorganism)
|
Stamm-
|
Stock, as a stock culture or stock solution
|
Standmuster
|
Retained sample; reserved sample
|
Stempel
|
Punch, or die, in a tabletting machine
|
Stickstoffüberlagerung |
Nitrogen blanket(ing)
|
Stufenausbeute
|
Stage (step) yield
|
Überschaumen |
Foaming over
|
unerwünschtes Ereignis |
Adverse event (clinical trial)
|
USP
|
United
States Pharmacopeia
|
Verfallsdatum
|
Expiration date
|
vermehrungsfähig |
Viable (microorganisms)
|
Verträglichkeit |
Tolerance for a drug in the sense of absence of
bad effects; acceptability;
|
Visum
|
Identifier (initials/signature) indicating
that someone has seen a process; perhaps Checked
by |
Vorfermenter
|
Prefermenter (used to grow inoculum for the main
fermenter)
|
Vorlage
|
Often a quantity of water or solvent added to a
reactor before solid reagents are added
|
Vorschrift
|
Procedure
|
Waage
|
Scale (for weighing) (see note below)
|
Weichgelatinkapsel
|
Soft gelatin capsule
|
WFI
|
Water for Injection
|
Wirksamkeit
|
Efficacy, activity
|
WP
|
Water, purified; PW; purified water
|
z. A. zur Analysis
|
Analytical grade (needs statement of limits of
impurities)
|
Zellernte
|
Cell harvest
|
Zellfeuchtgewicht
|
Wet weight of cells
|
Zelltrockengewicht
|
Dry weight of cells
|
A "balance" was originally an equal-arm balance, with a pan
hanging from the end of each arm. The item to be weighed was placed on
one pan, and "balanced" by adding known weights to the other
pan, or, for very small weights, along one arm. Such a balance was typically
inside a wooden case with glass windows to avoid air currents, and was
used in a chemical laboratory to weigh items of up to about 100 grams
to a precision of about 0.0001 g. It was often called an "analytical
balance". A long pointer at the center of the beam was used to determine
"balance", usually defined as the condition in which the pointer
would swing equally far to each side of center. The center of the beam
had a "knife-edge", such as an agate prism sitting on a hard
plate. Careful handling was required to avoid chipping the knife-edge.
The "torsion balance" had the beam supported on a metal ribbon
which twisted somewhat when the system was out of balance. It was not
usually enclosed, and was not as sensitive.
Other weighing instruments, not "equal arm" were often also
called balances. The typical example was the triple-beam balance, which
had a pan on which the item being weighed was placed, and three calibrated
'beams' along which weights were slid to bring the system to balance.
Such a balance might have one beam calibrated at 100 gram intervals up
to 1000 grams, another beam at 10-gram intervals up to 100 g, and the
third beam calibrated in grams and tenths of grams.
More recently, the "equal arm" principle has been more or less
abandoned even for analytical balances, with known weights added mechanically
inside the balance case. They were still called "balances",
but with only one pan used, these became known as "single-pan"
balances. The 'balance' condition was indicated by a scale projected on
a ground-glass window on the front. "Analytical" types usually
have a glass case with sliding windows for adding materials. "Top-loaders"
are used for higher weights up to a few kilograms.
Still more recently, the concept of 'balance' has changed from a mechanical
balance to electrically balancing the weight of the sample. These balances
typically provide a digital display of the weight. They look much like
the single-pan balances mentioned above.
Microbalances for weighing very small loads once were made using a quartz
fiber with the sample hung at the end. The deflection of the fiber was
read against a scale calibrated with known weights. They have largely
been replaced by electrobalances ("Cahn" was an early model).
Copyright © 2010 Denzel Dyer, all rights reserved.